A vacuum removes air dissolved in or mixed throughout the silicone. It cannot remove air trapped by the geometry in a pocket with no route out.
A deep blind recess, a sharp internal corner at the top of a form, or any feature that creates a closed void when the mould is poured can hold air, whatever the pressure in the chamber. The fix is to decide the orientation and split line before anything is mixed. Sometimes, the part itself may need to change. This is a design for manufacture conversation, not a process setting.
Vacuum does not improve a poor master. If your master has print lines, a scratch or a soft edge, degassing will reproduce every one of them perfectly. Vacuum casting makes a good master pattern more valuable, not less, because there is nothing left to hide behind.
There are a few practical limits worth knowing. A vacuum cast mould costs more than a straight cast mould because it involves more processing. The size of your work is limited by the chamber it needs to fit in, and the process does not extend mould life.
A vacuum cast mould wears out like any other silicone mould. If you need repeatable fine detail over years rather than seasons, a hard tool in compression will hold that detail more consistently than any soft mould.